BDBM412358 1-(4-Pyrazol-1-ylmethyl-benzyl)-1H-[1,2,3]triazole-4-carboxylic acid (1-amino-6,7-dihydro-5H-[2]pyrindin-7-yl)-amide::US10399961, Example 2

SMILES Nc1nccc2CCC(NC(=O)c3cn(Cc4ccc(Cn5cccn5)cc4)nn3)c12

InChI Key InChIKey=BAZJOBLYOILXCF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 412358   

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM412358(US10399961, Example 2 | 1-(4-Pyrazol-1-ylmethyl-be...)
Affinity DataIC50: 600nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 hr at Room Temperature with 0.10...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent