BDBM412136 US10392402, Compound A::US10738007, Compound A::US10807966, Compound A::US11555039, Compound ID A

SMILES Cc1c[nH]c2nccc(Oc3c(F)cc(Nc4cc(Cl)nc(N)n4)cc3F)c12

InChI Key InChIKey=NRSGWEVTVGZDFC-UHFFFAOYSA-N

Data  32 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 412136   

TargetTyrosine-protein kinase receptor UFO(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 6.70E+3nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.10nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 0.600nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 303nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 252nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetcAMP-dependent protein kinase catalytic subunit gamma(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase 3(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 7(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 3.30nMAssay Description:The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
7/20/2020
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDeath-associated protein kinase 3(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 4.10E+3nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 7.40E+3nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 2.80nMAssay Description:n general, kinases regulate many important cellular activities including cell growth, signaling, metabolism, etc. Different kinases have distinct fun...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
3/12/2023
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 3.30nMAssay Description:n general, kinases regulate many important cellular activities including cell growth, signaling, metabolism, etc. Different kinases have distinct fun...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
3/12/2023
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 2.80nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 3.30nMAssay Description:The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 2.80nMAssay Description:The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
4/4/2021
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 3.30nMAssay Description:The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
4/4/2021
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 2.80nMAssay Description:The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
7/20/2020
Entry Details
Go to US Patent