BDBM411560 (R)-((2-(2-amino-6- methoxypyridin-4-yl)-6- (3-methylmorpholino)- pyrimidin-4-yl)imino)- dimethyl-lambda6-sulfanone::US10392376, Example 111::US10800769, Example 111::US11434233, Example 111
SMILES COc1cc(cc(N)n1)-c1nc(cc(n1)N1CCOC[C@H]1C)N=S(C)(C)=O
InChI Key InChIKey=IIESYNOIUJVTSG-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 411560
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas
US Patent
University Of Texas
US Patent
Affinity DataIC50: 123nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoSimilars
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas
US Patent
University Of Texas
US Patent
Affinity DataIC50: 123nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoSimilars
TargetSerine/threonine-protein kinase ATR(Human)
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 123nMAssay Description:Inhibition of human full-length FLAG-TEV-tagged ATR/His6-tagged ATRIP expressed in HEK293 cells using FAM-labeled RAD17 peptide and ATP as substrate ...More data for this Ligand-Target Pair
Ligand InfoSimilars
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas
US Patent
University Of Texas
US Patent
Affinity DataIC50: 123nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoSimilars
TargetSerine/threonine-protein kinase ATR(Human)
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 273nMAssay Description:Inhibition of ATR in 4-NQO treated human HT-29 cells assessed as inhibition of Chk1 phosphorylation at Ser345 residue incubated for 90 mins followed ...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 273nMAssay Description:Inhibitors of ATR kinase are effective at inhibiting the ATR-driven phosphorylation of the downstream target Chk1 kinase at Serine 345, following the...More data for this Ligand-Target Pair
Ligand InfoSimilars
TargetSerine/threonine-protein kinase mTOR(Human)
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 2.21E+3nMAssay Description:Inhibition of mTOR (unknown origin) by LANCE Ultra assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
TargetSerine/threonine-protein kinase mTOR(Human)
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 8.26E+3nMAssay Description:Inhibition of mTOR in human HT-29 cells assessed as inhibition of S6 ribosomal protein phosphorylation at Ser 235/236 residue incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoSimilars