BDBM411535 (R)-((2-(2-(difluoro- methyl)-1H-benzo[d]- imidazol-1-yl)-6-(3- methylmorpholino)- pyrimidin-4-yl)imino)- dimethyl-lambda6-sulfanone::US10392376, Example 86::US10800769, Example 86::US11434233, Example 86

SMILES C[C@@H]1COCCN1c1cc(N=S(C)(C)=O)nc(n1)-n1c(nc2ccccc12)C(F)F

InChI Key InChIKey=CKDGBYCNDOKXHF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 411535   

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas

US Patent
LigandPNGBDBM411535(US10392376, Example 86 | (R)-((2-(2-(difluoro- met...)
Affinity DataIC50: 0.400nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/20/2020
Entry Details
Go to US Patent

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas

US Patent
LigandPNGBDBM411535(US10392376, Example 86 | (R)-((2-(2-(difluoro- met...)
Affinity DataIC50: 0.400nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
University Of Texas

US Patent
LigandPNGBDBM411535(US10392376, Example 86 | (R)-((2-(2-(difluoro- met...)
Affinity DataIC50: 28nMAssay Description:Inhibitors of ATR kinase are effective at inhibiting the ATR-driven phosphorylation of the downstream target Chk1 kinase at Serine 345, following the...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas

US Patent
LigandPNGBDBM411535(US10392376, Example 86 | (R)-((2-(2-(difluoro- met...)
Affinity DataIC50: 0.400nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
11/13/2022
Entry Details
Go to US Patent