BDBM411519 (R)-((2-(2-ethyl-1H- benzo[d]imidazol-1-yl)- 6-(3-methyl- morpholino)pyrimidin-4- yl)imino)dimethyl-lambda6- sulfanone::US10392376, Example 70::US10800769, Example 70::US11434233, Example 70

SMILES CCc1nc2ccccc2n1-c1nc(cc(n1)N1CCOC[C@H]1C)N=S(C)(C)=O

InChI Key InChIKey=WVPFDMOAIPTCRI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 411519   

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas

US Patent
LigandPNGBDBM411519(US10392376, Example 70 | (R)-((2-(2-ethyl-1H- benz...)
Affinity DataIC50: 3nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/20/2020
Entry Details
Go to US Patent

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas

US Patent
LigandPNGBDBM411519(US10392376, Example 70 | (R)-((2-(2-ethyl-1H- benz...)
Affinity DataIC50: 3nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
University Of Texas

US Patent
LigandPNGBDBM411519(US10392376, Example 70 | (R)-((2-(2-ethyl-1H- benz...)
Affinity DataIC50: 48nMAssay Description:Inhibitors of ATR kinase are effective at inhibiting the ATR-driven phosphorylation of the downstream target Chk1 kinase at Serine 345, following the...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas

US Patent
LigandPNGBDBM411519(US10392376, Example 70 | (R)-((2-(2-ethyl-1H- benz...)
Affinity DataIC50: 3nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
11/13/2022
Entry Details
Go to US Patent