BDBM411516 (R)-2-hydroxy-1-(1-((6- (3-methylmorpholino)-2- (1H-pyrrolo[2,3-b]- pyridin-4-yl)pyrimidin-4- yl)imino)-1-oxido-1lambda6- thiomorpholino)ethan-1- one::US10392376, Example 67::US10800769, Example 67::US11434233, Example 67

SMILES C[C@@H]1COCCN1c1cc(N=S2(=O)CCN(CC2)C(=O)CO)nc(n1)-c1ccnc2[nH]ccc12

InChI Key InChIKey=NVZMSEJMRFYPED-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 411516   

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas

US Patent
LigandPNGBDBM411516(US10392376, Example 67 | (R)-2-hydroxy-1-(1-((6- (...)
Affinity DataIC50: 3nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/20/2020
Entry Details
Go to US Patent

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas

US Patent
LigandPNGBDBM411516(US10392376, Example 67 | (R)-2-hydroxy-1-(1-((6- (...)
Affinity DataIC50: 3nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
University Of Texas

US Patent
LigandPNGBDBM411516(US10392376, Example 67 | (R)-2-hydroxy-1-(1-((6- (...)
Affinity DataIC50: 168nMAssay Description:Inhibitors of ATR kinase are effective at inhibiting the ATR-driven phosphorylation of the downstream target Chk1 kinase at Serine 345, following the...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas

US Patent
LigandPNGBDBM411516(US10392376, Example 67 | (R)-2-hydroxy-1-(1-((6- (...)
Affinity DataIC50: 3nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
11/13/2022
Entry Details
Go to US Patent