BDBM410185 US10370379, Compound 2::US11059827, Compound 2

SMILES F[C@H]1C[C@@H](N(C1)c1ccn2ncc(C#N)c2n1)c1cc(F)ccc1F

InChI Key InChIKey=TWIWYHDFCRSDJD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 410185   

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410185(US10370379, Compound 2 | US11059827, Compound 2)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410185(US10370379, Compound 2 | US11059827, Compound 2)
Affinity DataIC50: 10nMAssay Description:Inhibition of NTRK1 in human KM12 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410185(US10370379, Compound 2 | US11059827, Compound 2)
Affinity DataIC50: 100nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
Go to US Patent