BDBM410154 US10370375, Example 2

SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2[nH]cnc12

InChI Key InChIKey=UXILTNCWMACSJY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 410154   

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Elanco Tiergesundheit

US Patent
LigandPNGBDBM410154(US10370375, Example 2)
Affinity DataIC50: 582nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3 [811-1124](Human)
Elanco Tiergesundheit

US Patent
LigandPNGBDBM410154(US10370375, Example 2)
Affinity DataIC50: 1.89E+3nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [888-1187](Human)
Elanco Tiergesundheit

US Patent
LigandPNGBDBM410154(US10370375, Example 2)
Affinity DataIC50: 4.59E+3nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent