BDBM409930 US10370333, Example XII-5

SMILES NC(=O)c1cncc(NS(=O)(=O)c2cc(Cl)ccc2OC(F)(F)F)c1

InChI Key InChIKey=CQUTZNUBABXTRE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 409930   

TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford-Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM409930(US10370333, Example XII-5)
Affinity DataIC50: 550nMAssay Description:To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford-Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM409930(US10370333, Example XII-5)
Affinity DataIC50: 1.87E+4nMAssay Description:Inhibition of TNAP (unknown origin) in whole blood using pNPP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford-Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM409930(US10370333, Example XII-5)
Affinity DataIC50: 432nMAssay Description:Inhibition of TNAP (unknown origin) using PPi as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed