BDBM409788 US10370333, Example III-3::US10370333, Example XIII-12

SMILES COc1ccc(cc1)-c1cncc(NS(=O)(=O)c2cc(Cl)ccc2OC)c1

InChI Key InChIKey=GSJUYLFAODJCMV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 409788   

TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford-Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM409788(US10370333, Example XIII-12 | US10370333, Example ...)
Affinity DataIC50: 550nMAssay Description:To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford-Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM409788(US10370333, Example XIII-12 | US10370333, Example ...)
Affinity DataIC50: 550nMAssay Description:To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford-Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM409788(US10370333, Example XIII-12 | US10370333, Example ...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of TNAP (unknown origin) in whole blood using pNPP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford-Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM409788(US10370333, Example XIII-12 | US10370333, Example ...)
Affinity DataIC50: 23nMAssay Description:Inhibition of TNAP (unknown origin) using PPi as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed