BDBM409623 2-[6-(3-Chlorophenyl)-3-fluoro-pyrrolo[3,2-b]pyridin-1-yl]-1-(3-::US10377753, Example 489

SMILES FC1CN(C1)C(=O)Cn1cc(F)c2ncc(cc12)-c1cccc(Cl)c1

InChI Key InChIKey=SFBLMCASPNSIRO-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 409623   

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Amri

Curated by ChEMBL

LigandBDBM409623(2-[6-(3-Chlorophenyl)-3-fluoro-pyrrolo[3,2-b]pyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:Modulation of recombinant human GluN1/GluN2B NMDA receptor expressed in mammalian cells assessed as inhibition of glutamate/glycine-induced intracell...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
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TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Janssen Pharmaceutica

US Patent

LigandBDBM409623(2-[6-(3-Chlorophenyl)-3-fluoro-pyrrolo[3,2-b]pyrid...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
7/6/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL