BDBM409572 N,N-Dimethyl-2-[6-[5-(trifluoromethyl)-2-thienyl]pyrrolo[3,2-::US10377753, Example 438

SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(s1)C(F)(F)F

InChI Key InChIKey=LPFCXGVNLRXWCM-UHFFFAOYSA-N

Data  1 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 409572   

TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM409572(N,N-Dimethyl-2-[6-[5-(trifluoromethyl)-2-thienyl]p...)
Affinity DataIC50: 251nMAssay Description:The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409572(N,N-Dimethyl-2-[6-[5-(trifluoromethyl)-2-thienyl]p...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]dofetilide from recombinant human ERG expressed in HEK293 cell membranes measured after 80 mins by TopCount scintillation analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409572(N,N-Dimethyl-2-[6-[5-(trifluoromethyl)-2-thienyl]p...)
Affinity DataIC50: 47nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409572(N,N-Dimethyl-2-[6-[5-(trifluoromethyl)-2-thienyl]p...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409572(N,N-Dimethyl-2-[6-[5-(trifluoromethyl)-2-thienyl]p...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409572(N,N-Dimethyl-2-[6-[5-(trifluoromethyl)-2-thienyl]p...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409572(N,N-Dimethyl-2-[6-[5-(trifluoromethyl)-2-thienyl]p...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409572(N,N-Dimethyl-2-[6-[5-(trifluoromethyl)-2-thienyl]p...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409572(N,N-Dimethyl-2-[6-[5-(trifluoromethyl)-2-thienyl]p...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409572(N,N-Dimethyl-2-[6-[5-(trifluoromethyl)-2-thienyl]p...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells measured after 5 mins by Qpatch methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409572(N,N-Dimethyl-2-[6-[5-(trifluoromethyl)-2-thienyl]p...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed