BDBM409024 US10377744, Compound No. 44::US11123311, Compound 44::US11723929, Compound 44

SMILES CC[C@H](C)C(=O)N1CCC(CC1)NC(=O)Nc1ccc(OC(F)(F)F)c(Cl)c1

InChI Key InChIKey=VPKMDSZIAXLIOM-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 409024   

TargetBifunctional epoxide hydrolase 2(Human)
Eicosis

US Patent
LigandPNGBDBM409024(US10377744, Compound No. 44 | US11123311, Compound...)
Affinity DataKi:  3.35nMAssay Description:FRET assays to determine Ki for the compounds of Table I were carried out as described previously (Lee et al. Analytical Biochemistry 434 (2013) 259-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetBifunctional epoxide hydrolase 2(Human)
Eicosis

US Patent
LigandPNGBDBM409024(US10377744, Compound No. 44 | US11123311, Compound...)
Affinity DataKi:  3.35nMAssay Description:FRET assays to determine Ki for the compounds of Table I were carried out as described previously (Lee et al. Analytical Biochemistry 434 (2013) 259-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetBifunctional epoxide hydrolase 2(Human)
Eicosis

US Patent
LigandPNGBDBM409024(US10377744, Compound No. 44 | US11123311, Compound...)
Affinity DataKi:  3.35nMAssay Description:Any of a number of standard assays for determining epoxide hydrolase activity can be used to determine inhibition of sEH. For example, suitable assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
Go to US Patent

TargetEpoxide hydrolase 1(Human)
University of California

US Patent
LigandPNGBDBM409024(US10377744, Compound No. 44 | US11123311, Compound...)
Affinity DataKi:  3.35nMAssay Description:Scores of sEH inhibitors are known, of a variety of chemical structures. Derivatives in which the urea, carbamate or amide pharmacophore are particul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2023
Entry Details
Go to US Patent

TargetBifunctional epoxide hydrolase 2(Human)
Eicosis

US Patent
LigandPNGBDBM409024(US10377744, Compound No. 44 | US11123311, Compound...)
Affinity DataKi:  3.40nMAssay Description:Inhibition of recombinant human sEH expressed in baculovirus expression system assessed as reduction in ACPU binding incubated for 1 hr by FRET displ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed