BDBM409013 US10377744, Compound No. 33::US11123311, Compound 33::US11723929, Compound 33

SMILES Fc1cc(NC(=O)NC2CCN(CC2)C(=O)C2CCOC2)ccc1C(F)(F)F

InChI Key InChIKey=ZUWZREBWJHJAFL-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 409013   

TargetBifunctional epoxide hydrolase 2(Human)
Eicosis

US Patent
LigandPNGBDBM409013(US10377744, Compound No. 33 | US11123311, Compound...)
Affinity DataKi:  2.09nMAssay Description:FRET assays to determine Ki for the compounds of Table I were carried out as described previously (Lee et al. Analytical Biochemistry 434 (2013) 259-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
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TargetBifunctional epoxide hydrolase 2(Human)
Eicosis

US Patent
LigandPNGBDBM409013(US10377744, Compound No. 33 | US11123311, Compound...)
Affinity DataKi:  2.09nMAssay Description:Any of a number of standard assays for determining epoxide hydrolase activity can be used to determine inhibition of sEH. For example, suitable assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
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TargetEpoxide hydrolase 1(Human)
University of California

US Patent
LigandPNGBDBM409013(US10377744, Compound No. 33 | US11123311, Compound...)
Affinity DataKi:  2.09nMAssay Description:Scores of sEH inhibitors are known, of a variety of chemical structures. Derivatives in which the urea, carbamate or amide pharmacophore are particul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2023
Entry Details
Go to US Patent