BDBM409005 US10377744, Compound No. 26::US11123311, Compound 26::US11723929, Compound 26

SMILES CC[C@H](C)C(=O)N1CCC(CC1)NC(=O)Nc1ccc(OC(F)(F)F)c(F)c1

InChI Key InChIKey=LHRXHTKENPCGSZ-UHFFFAOYSA-N

Data  6 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 409005   

TargetBifunctional epoxide hydrolase 2(Human)
Unitat Associada Al Csic

Curated by ChEMBL
LigandPNGBDBM409005(US10377744, Compound No. 26 | US11123311, Compound...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant sEH using CMNPC as substrate incubated for 5 mins by fluorescent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Unitat Associada Al Csic

Curated by ChEMBL
LigandPNGBDBM409005(US10377744, Compound No. 26 | US11123311, Compound...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant sEHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Unitat Associada Al Csic

Curated by ChEMBL
LigandPNGBDBM409005(US10377744, Compound No. 26 | US11123311, Compound...)
Affinity DataKi: <0.0500nMAssay Description:FRET assays to determine Ki for the compounds of Table I were carried out as described previously (Lee et al. Analytical Biochemistry 434 (2013) 259-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetBifunctional epoxide hydrolase 2(Human)
Unitat Associada Al Csic

Curated by ChEMBL
LigandPNGBDBM409005(US10377744, Compound No. 26 | US11123311, Compound...)
Affinity DataKi: <0.0500nMAssay Description:FRET assays to determine Ki for the compounds of Table I were carried out as described previously (Lee et al. Analytical Biochemistry 434 (2013) 259-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetBifunctional epoxide hydrolase 2(Human)
Unitat Associada Al Csic

Curated by ChEMBL
LigandPNGBDBM409005(US10377744, Compound No. 26 | US11123311, Compound...)
Affinity DataKi: <0.0500nMAssay Description:Any of a number of standard assays for determining epoxide hydrolase activity can be used to determine inhibition of sEH. For example, suitable assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
Go to US Patent

TargetBifunctional epoxide hydrolase 2(Human)
Unitat Associada Al Csic

Curated by ChEMBL
LigandPNGBDBM409005(US10377744, Compound No. 26 | US11123311, Compound...)
Affinity DataKi: <0.0500nMAssay Description:Binding affinity to purified recombinant human sEH by FRET-displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Unitat Associada Al Csic

Curated by ChEMBL
LigandPNGBDBM409005(US10377744, Compound No. 26 | US11123311, Compound...)
Affinity DataKi: <0.0500nMAssay Description:Inhibition of recombinant human sEH expressed in baculovirus expression system assessed as reduction in ACPU binding incubated for 1 hr by FRET displ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetEpoxide hydrolase 1(Human)
University of California

US Patent
LigandPNGBDBM409005(US10377744, Compound No. 26 | US11123311, Compound...)
Affinity DataKi: <0.0500nMAssay Description:Scores of sEH inhibitors are known, of a variety of chemical structures. Derivatives in which the urea, carbamate or amide pharmacophore are particul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2023
Entry Details
Go to US Patent