BDBM408664 (R)-5-cyano-4-ethoxy-N-(1-(2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)piperidin-4-yl)picolinamide::US10364234, Example 2::US10759788, Example 2

SMILES CCOc1cc(ncc1C#N)C(=O)NC1CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)CC1

InChI Key InChIKey=IUZUNEYDOGGCHP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 408664   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408664(US10364234, Example 2 | (R)-5-cyano-4-ethoxy-N-(1-...)
Affinity DataIC50: 28nMAssay Description:The Inhibitory Activity of the Present Compounds on Human ROMK and Rat ROMK ChannelsThe method described hereafter was used for determining the inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
Go to US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Rat)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408664(US10364234, Example 2 | (R)-5-cyano-4-ethoxy-N-(1-...)
Affinity DataIC50: 89nMAssay Description:The Inhibitory Activity of the Present Compounds on Human ROMK and Rat ROMK ChannelsThe method described hereafter was used for determining the inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
Go to US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408664(US10364234, Example 2 | (R)-5-cyano-4-ethoxy-N-(1-...)
Affinity DataIC50: 28nMAssay Description:human ROMK and rat ROMK: 1. Materials and Instruments (1) FluxOR potassium ion channel assay (F10016, Invitrogen) (2) Ouabain (03125-1G, Sigma)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Rat)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408664(US10364234, Example 2 | (R)-5-cyano-4-ethoxy-N-(1-...)
Affinity DataIC50: 89nMAssay Description:human ROMK and rat ROMK: 1. Materials and Instruments (1) FluxOR potassium ion channel assay (F10016, Invitrogen) (2) Ouabain (03125-1G, Sigma)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent