BDBM408663 (R)-5-cyano-N-(1-(2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)piperidin-4-yl)-4-methoxypicolinamide::US10364234, Example 1::US10759788, Example 1

SMILES COc1cc(ncc1C#N)C(=O)NC1CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)CC1

InChI Key InChIKey=PJJXLIVFRBOUIZ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 408663   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408663(US10364234, Example 1 | US10759788, Example 1 | (R...)
Affinity DataIC50: 40nMAssay Description:The Inhibitory Activity of the Present Compounds on Human ROMK and Rat ROMK ChannelsThe method described hereafter was used for determining the inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
Go to US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Rat)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408663(US10364234, Example 1 | US10759788, Example 1 | (R...)
Affinity DataIC50: 192nMAssay Description:The Inhibitory Activity of the Present Compounds on Human ROMK and Rat ROMK ChannelsThe method described hereafter was used for determining the inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408663(US10364234, Example 1 | US10759788, Example 1 | (R...)
Affinity DataIC50: 4.37E+4nMAssay Description:The method described hereafter is used for determining the inhibitory activity of the present compounds on hERG1. Materials and Instruments(1) FluxOR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
Go to US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Rat)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408663(US10364234, Example 1 | US10759788, Example 1 | (R...)
Affinity DataIC50: 192nMAssay Description:human ROMK and rat ROMK: 1. Materials and Instruments (1) FluxOR potassium ion channel assay (F10016, Invitrogen) (2) Ouabain (03125-1G, Sigma)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408663(US10364234, Example 1 | US10759788, Example 1 | (R...)
Affinity DataIC50: 40nMAssay Description:human ROMK and rat ROMK: 1. Materials and Instruments (1) FluxOR potassium ion channel assay (F10016, Invitrogen) (2) Ouabain (03125-1G, Sigma)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408663(US10364234, Example 1 | US10759788, Example 1 | (R...)
Affinity DataIC50: 4.37E+4nMAssay Description:hERG: 1. Materials and Instruments (1) FluxOR potassium ion channel assay (F10016, invitrogen) (2) FlexStation3 microplate reader (molecular de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Rat)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408663(US10364234, Example 1 | US10759788, Example 1 | (R...)
Affinity DataIC50: 18.7nMAssay Description:human ROMK and rat ROMK: 1. Materials and Instruments (1) FluxOR potassium ion channel assay (F10016, Invitrogen) (2) Ouabain (03125-1G, Sigma)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent