BDBM408621 US10358436, Example A38

SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(n[nH]c4c3)-c3ccc(cc3)N3CCN(C)CC3)c2c1

InChI Key InChIKey=ZSMPGSBOZTVRAJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 408621   

TargetSerine/threonine-protein kinase PLK4 [1-391](Human)
University Health Network

US Patent
LigandPNGBDBM408621(US10358436, Example A38)
Affinity DataIC50: 100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
University Health Network

US Patent
LigandPNGBDBM408621(US10358436, Example A38)
Affinity DataIC50: 500nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
University Health Network

US Patent
LigandPNGBDBM408621(US10358436, Example A38)
Affinity DataIC50: 100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent