BDBM408613 US10358436, Example A31::US10358436, Example A85

SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(\C=C\c5ccc(nc5)N5CCN(C)CC5)n[nH]c4c3)c2c1

InChI Key InChIKey=XMHCFCMVNKTYOH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 408613   

TargetSerine/threonine-protein kinase PLK4 [1-391](Human)
University Health Network

US Patent
LigandPNGBDBM408613(US10358436, Example A85 | US10358436, Example A31)
Affinity DataIC50: 100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetAurora kinase A(Human)
University Health Network

US Patent
LigandPNGBDBM408613(US10358436, Example A85 | US10358436, Example A31)
Affinity DataIC50: 500nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
University Health Network

US Patent
LigandPNGBDBM408613(US10358436, Example A85 | US10358436, Example A31)
Affinity DataIC50: 100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase PLK4 [1-391](Human)
University Health Network

US Patent
LigandPNGBDBM408613(US10358436, Example A85 | US10358436, Example A31)
Affinity DataIC50: 100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent