BDBM408598 US10358446, Compound 128

SMILES Fc1cc(F)cc(Oc2ccc(cc2)-n2c3cnccc3n(-c3cccc(NC(=O)C=C)c3)c2=O)c1

InChI Key InChIKey=CLUYEBBJSXKZNL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 408598   

TargetTyrosine-protein kinase BTK(Human)
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM408598(US10358446, Compound 128)
Affinity DataIC50: 55nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Blk(Human)
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM408598(US10358446, Compound 128)
Affinity DataIC50: 550nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Lyn(Human)
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM408598(US10358446, Compound 128)
Affinity DataIC50: 1.00E+4nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Lck(Human)
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM408598(US10358446, Compound 128)
Affinity DataIC50: 1.00E+4nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent