BDBM408582 (R)- or (S)-6-(6-(2-Fluoro-4- (trifluoromethyl)phenyl)-6-methyl- 5,6-dihydro-4H-pyrolo[1,2- c][1,2,3]triazol-3-yl)-2- methylpyrimidin-4(3H)-one::US10358435, Example 97::US10358435, Example 98

SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2c1CCC2(C)c1ccc(cc1F)C(F)(F)F

InChI Key InChIKey=IBFYZQNTKSBWEN-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 408582   

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408582(US10358435, Example 98 | (R)- or (S)-6-(6-(2-Fluor...)
Affinity DataKi:  1.30nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408582(US10358435, Example 98 | (R)- or (S)-6-(6-(2-Fluor...)
Affinity DataKi:  1.5nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408582(US10358435, Example 98 | (R)- or (S)-6-(6-(2-Fluor...)
Affinity DataKi:  218nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent