BDBM408549 (R)- or (S)-6-(5-(1-(2- chloro-4-(trifluoromethyl)- phenyl)ethyl)-4H-1,2,4- triazol-3-yl)-2- methylpyrimidin-4(3H)-one::US10358435, Example 65::US10358435, Example 66

SMILES CC(c1nnc([nH]1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1Cl)C(F)(F)F

InChI Key InChIKey=MQZWABUQAFSUOS-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408549   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408549(US10358435, Example 66 | (R)- or (S)-6-(5-(1-(2- c...)
Affinity DataKi:  15.9nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408549(US10358435, Example 66 | (R)- or (S)-6-(5-(1-(2- c...)
Affinity DataKi:  525nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent