BDBM408529 (R)- or (S)-6-(5-butyl-1- (1-(2-chloro-4-(trifluoromethyl) phenyl)ethyl)-1H-1,2,3- triazol-4-yl)-2-methylpyrimidin- 4(3H)-one::US10358435, Example 45::US10358435, Example 46

SMILES CCCCc1c(nnn1C(C)c1ccc(cc1Cl)C(F)(F)F)-c1cc(=O)[nH]c(C)n1

InChI Key InChIKey=BJIIBGIOXABMLD-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408529   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408529((R)- or (S)-6-(5-butyl-1- (1-(2-chloro-4-(trifluor...)
Affinity DataKi:  9.20nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408529((R)- or (S)-6-(5-butyl-1- (1-(2-chloro-4-(trifluor...)
Affinity DataKi:  1.10E+3nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent