BDBM408523 (R)- or (S)-6-(1-(1-(2-fluoro-4- (trifluoromethyl)phenyl)-2- methylpropyl)-1H-1,2,3-triazol- 4-yl)-2-methylpyrimidin-4(3H)- one::US10358435, Example 39::US10358435, Example 40

SMILES CC(C)C(c1ccc(cc1F)C(F)(F)F)n1cc(nn1)-c1cc(=O)[nH]c(C)n1

InChI Key InChIKey=NHUBMHZFFOCSMC-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408523   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408523(US10358435, Example 40 | (R)- or (S)-6-(1-(1-(2-fl...)
Affinity DataKi:  7.20nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408523(US10358435, Example 40 | (R)- or (S)-6-(1-(1-(2-fl...)
Affinity DataKi:  22.6nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent