BDBM408498 US10358435, Example 19::cyclopropyl(2-fluoro-4- (trifluoromethyl) phenyl)methanol

SMILES OC(C1CC1)c1ccc(cc1F)C(F)(F)F

InChI Key InChIKey=OAJLHJNDJJZXAO-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408498   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408498(cyclopropyl(2-fluoro-4- (trifluoromethyl) phenyl)m...)
Affinity DataKi:  2.10nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408498(cyclopropyl(2-fluoro-4- (trifluoromethyl) phenyl)m...)
Affinity DataKi:  3.40nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent