BDBM408494 (E)-2-(but-1-enyl)-6-(1-(1-(2-fluoro- 4-(trifluoromethyl)phenyl)ethyl)-1H- 1,2,3-triazol-4-yl)pyrimidin-4(3H)- one::US10358435, Example 15

SMILES CC\C=C\c1nc(cc(=O)[nH]1)-c1cn(nn1)C(C)c1ccc(cc1F)C(F)(F)F

InChI Key InChIKey=JVNAQWWPVNZQGG-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408494   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408494((E)-2-(but-1-enyl)-6-(1-(1-(2-fluoro- 4-(trifluoro...)
Affinity DataKi:  4.70nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408494((E)-2-(but-1-enyl)-6-(1-(1-(2-fluoro- 4-(trifluoro...)
Affinity DataKi:  6.5nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent