BDBM408001 (R)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-(3- (dimethylamino)-2-fluoro-3- oxopropyl)-4-((4- hydroxybicyclo[2.2.2] octan-1-yl)amino) nicotinamide::US10336762, Compound 946

SMILES CN(C)C(=O)[C@H](F)CNC(=O)c1cnc(cc1NC12CCC(O)(CC1)CC2)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=QEPXNBAWNGRTIR-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408001   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM408001((R)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-(3-...)
Affinity DataIC50: 1nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM408001((R)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-(3-...)
Affinity DataEC50:  120nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent