BDBM407739 (R)-4-((2-(azetidin-1-yl) pyrimidin-5-yl)amino)-6- (3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-(2-fluoro- 3-hydroxy-3-methylbutyl) nicotinamide::US10336762, Compound 681

SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1Nc1cnc(nc1)N1CCC1)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=DXAQBDNZIWBECE-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407739   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 407739BDBM407739((R)-4-((2-(azetidin-1-yl) pyrimidin-5-yl)amino)-6-...)
Affinity DataIC50: 1nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 407739BDBM407739((R)-4-((2-(azetidin-1-yl) pyrimidin-5-yl)amino)-6-...)
Affinity DataEC50:  6nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent