BDBM4075 8-Ethyl-2-phenylamino-6-thiophene-3-yl-8H-pyrido-[2,3-d]pyrimidin-7-one::8-ethyl-2-(phenylamino)-6-(thiophen-3-yl)-7H,8H-pyrido[2,3-d]pyrimidin-7-one::pyrido[2,3-d]pyrimidin-7-one deriv. 48

SMILES CCn1c2nc(Nc3ccccc3)ncc2cc(-c2ccsc2)c1=O

InChI Key InChIKey=WPUHUROYCYWEDW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4075   

TargetPlatelet-derived growth factor receptor beta(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4075(8-ethyl-2-(phenylamino)-6-(thiophen-3-yl)-7H,8H-py...)
Affinity DataIC50: 410nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2005
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4075(8-ethyl-2-(phenylamino)-6-(thiophen-3-yl)-7H,8H-py...)
Affinity DataIC50: 4.10E+4nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4075(8-ethyl-2-(phenylamino)-6-(thiophen-3-yl)-7H,8H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2005
Entry Details Article
PubMed