BDBM407075 4-(((1R,3r,5S)-8- azabicyclo[3.2.1]octan-3- yl)amino)-6-(3-cyano- pyrrolo[1,2-b]pyridazin- 7-yl)-N-((R)-2-fluoro-3- hydroxy-3- methylbutyl)nicotinamide::US10336762, Compound 14::US10336762, Compound 24

SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1NC1CC2CCC(C1)N2)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=KPHVETZAJSNGEO-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 407075   

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407075(4-(((1R,3r,5S)-8- azabicyclo[3.2.1]octan-3- yl)ami...)
Affinity DataEC50:  626nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407075(4-(((1R,3r,5S)-8- azabicyclo[3.2.1]octan-3- yl)ami...)
Affinity DataIC50: 3nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407075(4-(((1R,3r,5S)-8- azabicyclo[3.2.1]octan-3- yl)ami...)
Affinity DataEC50:  642nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407075(4-(((1R,3r,5S)-8- azabicyclo[3.2.1]octan-3- yl)ami...)
Affinity DataIC50: 2nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent