BDBM407074 N-((1r,4r)-4-acetamido- cyclohexyl)-6-(3-cyano- pyrrolo[1,2-b]pyridazin- 7-yl)-4-(isopropylamino) nicotinamide::US10336762, Compound 13

SMILES CC(C)Nc1cc(ncc1C(=O)N[C@H]1CC[C@@H](CC1)NC(C)=O)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=IZWLTJBPWATULX-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407074   

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407074(N-((1r,4r)-4-acetamido- cyclohexyl)-6-(3-cyano- py...)
Affinity DataEC50:  79nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407074(N-((1r,4r)-4-acetamido- cyclohexyl)-6-(3-cyano- py...)
Affinity DataIC50: 1nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent