BDBM406961 4-N-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)-1-N, 1-N-dimethylcyclohexane-1,4-diamine::US10336761, Example 245

SMILES CN(C)C1CCC(CC1)NCc1ccn2nc(nc(Nc3ccncc3F)c12)-c1ccccn1

InChI Key InChIKey=QALWNDKPDOXZOK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 406961   

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM406961(4-N-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2...)
Affinity DataIC50: 1nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTGF-beta receptor type-2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM406961(4-N-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2...)
Affinity DataIC50: 7.60E+3nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent