BDBM406729 3-fluoro-N-[2-(4-methyl-1,3-thiazol-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine::US10336761, Example 12

SMILES Cc1csc(n1)-c1nc(Nc2ccncc2F)c2cccn2n1

InChI Key InChIKey=LNKMOULIMCFXDG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 406729   

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM406729(3-fluoro-N-[2-(4-methyl-1,3-thiazol-2-yl)pyrrolo[2...)
Affinity DataIC50: 0.800nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTGF-beta receptor type-2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM406729(3-fluoro-N-[2-(4-methyl-1,3-thiazol-2-yl)pyrrolo[2...)
Affinity DataIC50: 330nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent