BDBM406215 1-((r-1,t-2,c-3)-2- hydroxy-3-methoxy- 4,4-dimethyl-1,2,3,4- tetrahydronaphthalen- 1-yl)-3-(4-methyl-3- ((1-methylpiperidin-4- yl)methoxy)-1-phenyl- 1H-pyrazol-5-yl)urea::US10351575, Example 158::US10889589, EX. # 158

SMILES CO[C@@H]1[C@@H](O)[C@H](NC(=O)Nc2c(C)c(OCC3CCN(C)CC3)nn2-c2ccccc2)c2ccccc2C1(C)C

InChI Key InChIKey=DNOBEBQKQJUSNK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 406215   

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM406215(1-((r-1,t-2,c-3)-2- hydroxy-3-methoxy- 4,4-dimethy...)
Affinity DataIC50: 100nMAssay Description:TrkA binding activity was determined in a TrkA LanthaScreen Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM406215(1-((r-1,t-2,c-3)-2- hydroxy-3-methoxy- 4,4-dimethy...)
Affinity DataIC50: 100nMAssay Description:TrkA binding activity was determined in a TrkA LanthaScreen Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent