BDBM406212 1-((r-1,t-2,t-3)-2-hydroxy- 3-methoxy-4,4-dimethyl- 1,2,3,4- tetrahydronaphthalen-1- yl)-3-(4-methyl-3-(2- methylpyrimidin-5-yl)-1- phenyl-1H-pyrazol-5- yl)urea::US10351575, Example 155::US10889589, EX. # 155

SMILES CO[C@H]1[C@@H](O)[C@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc(C)nc2)c2ccccc2C1(C)C

InChI Key InChIKey=YMNQUMZOKQHEJK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 406212   

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM406212(1-((r-1,t-2,t-3)-2-hydroxy- 3-methoxy-4,4-dimethyl...)
Affinity DataIC50: 100nMAssay Description:TrkA binding activity was determined in a TrkA LanthaScreen Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM406212(1-((r-1,t-2,t-3)-2-hydroxy- 3-methoxy-4,4-dimethyl...)
Affinity DataIC50: 100nMAssay Description:TrkA binding activity was determined in a TrkA LanthaScreen Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details
US Patent