BDBM406178 5-(3-(trans-2-hydroxy- 4,4-dimethyl-1,2,3,4- tetrahydronaphthalen-1- yl)ureido)-N,4-dimethyl- 1-phenyl-1H-pyrazole-3- carboxamide::US10351575, Example 124::US10889589, EX. # 124

SMILES CNC(=O)c1nn(c(NC(=O)NC2[C@H](O)CC(C)(C)c3ccccc23)c1C)-c1ccccc1

InChI Key InChIKey=XOTIYMHNSWYAKE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 406178   

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM406178(5-(3-(trans-2-hydroxy- 4,4-dimethyl-1,2,3,4- tetra...)
Affinity DataIC50: 100nMAssay Description:TrkA binding activity was determined in a TrkA LanthaScreen Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM406178(5-(3-(trans-2-hydroxy- 4,4-dimethyl-1,2,3,4- tetra...)
Affinity DataIC50: 100nMAssay Description:TrkA binding activity was determined in a TrkA LanthaScreen Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent