BDBM406109 1-(3-ethoxy-4-methyl-1- phenyl-1H-pyrazol-5-yl)-3- (trans-2'-hydroxy-2',3'- dihydrospiro[cyclopropane- 1,1-inden]-3-yl)urea::US10351575, Example 61

SMILES CCOc1nn(c(NC(=O)NC2[C@H](O)C3(CC3)c3ccccc23)c1C)-c1ccccc1

InChI Key InChIKey=XWOAORQAXFXEEJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 406109   

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM406109(1-(3-ethoxy-4-methyl-1- phenyl-1H-pyrazol-5-yl)-3-...)
Affinity DataIC50: 100nMAssay Description:TrkA binding activity was determined in a TrkA LanthaScreen Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details
Go to US Patent