BDBM406072 1-(4-methyl-3-(1-methyl-6- oxo-1,6-dihydropyridin-3- yl)-1-phenyl-1H-pyrazol-5- yl)-3-(2-(2,2,2- trifluoroethyl)-1,2,3,4- tetrahydroisoquinolin-4- yl)urea::US10351575, Example 26::US10889589, EX. # 26

SMILES Cc1c(NC(=O)NC2CN(CC(F)(F)F)Cc3ccccc23)n(nc1-c1ccc(=O)n(C)c1)-c1ccccc1

InChI Key InChIKey=QFVKCJIMTPOLNG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 406072   

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM406072(1-(4-methyl-3-(1-methyl-6- oxo-1,6-dihydropyridin-...)
Affinity DataIC50: 100nMAssay Description:TrkA binding activity was determined in a TrkA LanthaScreen Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM406072(1-(4-methyl-3-(1-methyl-6- oxo-1,6-dihydropyridin-...)
Affinity DataIC50: 100nMAssay Description:TrkA binding activity was determined in a TrkA LanthaScreen Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent