BDBM406049 (S)-1-(2-phenyl-2,4,5,6- tetrahydrocyclopenta[c]pyrazol- 3-yl)-3-(1,2,3,4- tetrahydronaphthalen-1-yl)urea::US10351575, Example 3::US10889589, EX. # 3

SMILES O=C(N[C@H]1CCCc2ccccc12)Nc1c2CCCc2nn1-c1ccccc1

InChI Key InChIKey=LOPQPPJEBVQXTN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 406049   

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM406049((S)-1-(2-phenyl-2,4,5,6- tetrahydrocyclopenta[c]py...)
Affinity DataIC50: 100nMAssay Description:TrkA binding activity was determined in a TrkA LanthaScreen Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM406049((S)-1-(2-phenyl-2,4,5,6- tetrahydrocyclopenta[c]py...)
Affinity DataIC50: 100nMAssay Description:TrkA binding activity was determined in a TrkA LanthaScreen Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent