BDBM4057 2-Amino-8-benzyl-6-(2,6-dichlorophenyl)-8H-pyrido-[2,3-d]pyrimidin-7-one::2-amino-8-benzyl-6-(2,6-dichlorophenyl)-7H,8H-pyrido[2,3-d]pyrimidin-7-one::pyrido[2,3-d]pyrimidin-7-one deriv. 12

SMILES Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(Cc3ccccc3)c2n1

InChI Key InChIKey=PEKQQOAQBPEQDZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4057   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4057(2-amino-8-benzyl-6-(2,6-dichlorophenyl)-7H,8H-pyri...)
Affinity DataIC50: 160nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4057(2-amino-8-benzyl-6-(2,6-dichlorophenyl)-7H,8H-pyri...)
Affinity DataIC50: 1.40E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2005
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4057(2-amino-8-benzyl-6-(2,6-dichlorophenyl)-7H,8H-pyri...)
Affinity DataIC50: 4.20E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2005
Entry Details Article
PubMed