BDBM405597 US10351547, Compound 2-11::US10597377, Compound 2-11

SMILES NC1CCN(CC1)c1c(cnc2ccccc12)-c1cc(Cl)cc(Cl)c1

InChI Key InChIKey=LQQAGKUKYRVPHN-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 405597   

TargetSomatostatin receptor type 2(Human)
Crinetics Pharmaceuticals

US Patent
LigandPNGBDBM405597(US10351547, Compound 2-11 | US10597377, Compound 2...)
Affinity DataEC50:  55nMAssay Description:Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details
Go to US Patent

TargetSomatostatin receptor type 2(Human)
Crinetics Pharmaceuticals

US Patent
LigandPNGBDBM405597(US10351547, Compound 2-11 | US10597377, Compound 2...)
Affinity DataEC50:  55nMAssay Description:Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent

TargetSomatostatin receptor type 2(Human)
Crinetics Pharmaceuticals

US Patent
LigandPNGBDBM405597(US10351547, Compound 2-11 | US10597377, Compound 2...)
Affinity DataEC50:  140nMAssay Description:Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSomatostatin receptor type 4(Human)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM405597(US10351547, Compound 2-11 | US10597377, Compound 2...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human SST4 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed