BDBM405587 US10351547, Compound 2-1::US10597377, Compound 2-1

SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CCC(N)CC1)-c1cccc(C#N)c1O

InChI Key InChIKey=UJWVFOZDAGJLCH-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 405587   

TargetSomatostatin receptor type 2(Human)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM405587(US10351547, Compound 2-1 | US10597377, Compound 2-...)
Affinity DataEC50:  0.170nMAssay Description:Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSomatostatin receptor type 2(Human)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM405587(US10351547, Compound 2-1 | US10597377, Compound 2-...)
Affinity DataEC50: <10nMAssay Description:Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details
US Patent

TargetSomatostatin receptor type 2(Human)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM405587(US10351547, Compound 2-1 | US10597377, Compound 2-...)
Affinity DataEC50: <10nMAssay Description:Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent