BDBM404733 5-{4-[4-({[3- (trifluoromethoxy)phenyl]methyl} carbamoyl)-1H-1,2,3-triazol-1-yl] butyl}-N-{[5-(trifluoromethyl) pyridin-2-yl]methyl}-1,3,4- thiadiazole-2-carboxamide::US10344025, Example 77::US11370786, Example 77

SMILES FC(F)(F)Oc1cccc(CNC(=O)c2cn(CCCCc3nnc(s3)C(=O)NCc3ccc(cn3)C(F)(F)F)nn2)c1

InChI Key InChIKey=IHZLPYMXRQKFHT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 404733   

TargetGlutaminase kidney isoform, mitochondrial(Human)
The University of Texas System

US Patent
LigandPNGBDBM404733(5-{4-[4-({[3- (trifluoromethoxy)phenyl]methyl} car...)
Affinity DataIC50: 100nMAssay Description:The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
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TargetGlutaminase kidney isoform, mitochondrial(Human)
The University of Texas System

US Patent
LigandPNGBDBM404733(5-{4-[4-({[3- (trifluoromethoxy)phenyl]methyl} car...)
Affinity DataIC50: 100nMAssay Description:The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent