BDBM404676 N-benzyl-1-{4-[5-(2- phenylacetamido)-1,3,4- thiadiazol-2-yl]butyl}-1H-1,2,3- triazole-4-carboxamide::US10344025, Example 15::US11370786, Example 15

SMILES O=C(Cc1ccccc1)Nc1nnc(CCCCn2cc(nn2)C(=O)NCc2ccccc2)s1

InChI Key InChIKey=PYYGSHPKPLPMTQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 404676   

TargetGlutaminase kidney isoform, mitochondrial(Human)
The University of Texas System

US Patent
LigandPNGBDBM404676(N-benzyl-1-{4-[5-(2- phenylacetamido)-1,3,4- thiad...)
Affinity DataIC50: 100nMAssay Description:The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
The University of Texas System

US Patent
LigandPNGBDBM404676(N-benzyl-1-{4-[5-(2- phenylacetamido)-1,3,4- thiad...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human GAC after 10 mins by glutamate oxidase coupled Amplex UltraRed dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
The University of Texas System

US Patent
LigandPNGBDBM404676(N-benzyl-1-{4-[5-(2- phenylacetamido)-1,3,4- thiad...)
Affinity DataIC50: 100nMAssay Description:The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent