BDBM404640 4-((R or S)-1-(2-chloro- 6-cyclopropyl-3- fluorobenzoyl)-6- (hydroxymethyl)- 4,5,6,7-tetrahydro-1H- indaozl-3-yl)cyclohex- 3-ene-1-carboxylic acid::US10344000, Example 7B

SMILES OCC1CCc2c(C1)n(nc2C1=CCC(CC1)C(O)=O)C(=O)c1c(Cl)c(F)ccc1C1CC1

InChI Key InChIKey=IGYAUHQCRPJGPR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 404640   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404640(4-((R or S)-1-(2-chloro- 6-cyclopropyl-3- fluorobe...)
Affinity DataIC50: 14nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2020
Entry Details
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