BDBM404626 4-(1-{[2-chloro-6-(1- methylcyclopropyl) phenyl]carbonyl}- 1,4,5,6- tetrahydrocyclopenta [c]pyrazol-3- yl)cyclohex-3-ene-1- carboxylic acid::US10344000, Example 1E

SMILES CC1(CC1)c1cccc(Cl)c1C(=O)n1nc(c2CCCc12)C1=CCC(CC1)C(O)=O

InChI Key InChIKey=ANEMYDHYMMRIOU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 404626   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404626(4-(1-{[2-chloro-6-(1- methylcyclopropyl) phenyl]ca...)
Affinity DataIC50: 33nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2020
Entry Details
Go to US Patent