BDBM404588 (R)-N-(1-cyanopyrrolidin-3-yl)-1-(4-cyclopropylpyrimidin-2-yl)-N-methylindoline-5-carboxamide::US10343992, Example 240::US10689345, Example 240::US11053198, Example 240::US11390584, Example 240

SMILES CN([C@@H]1CCN(C1)C#N)C(=O)c1ccc2N(CCc2c1)c1nccc(n1)C1CC1

InChI Key InChIKey=LILFYGVHFJUJNI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 404588   

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Missions Therapeutics

US Patent
LigandPNGBDBM404588((R)-N-(1-cyanopyrrolidin-3-yl)-1-(4-cyclopropylpyr...)
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2020
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Missions Therapeutics

US Patent
LigandPNGBDBM404588((R)-N-(1-cyanopyrrolidin-3-yl)-1-(4-cyclopropylpyr...)
Affinity DataIC50: 100nMAssay Description:USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Missions Therapeutics

US Patent
LigandPNGBDBM404588((R)-N-(1-cyanopyrrolidin-3-yl)-1-(4-cyclopropylpyr...)
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Missions Therapeutics

US Patent
LigandPNGBDBM404588((R)-N-(1-cyanopyrrolidin-3-yl)-1-(4-cyclopropylpyr...)
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent