BDBM404569 (R)-N-(1-cyanopyrrolidin-3-yl)-3-(3-methoxyphenyl)isoxazole-5-carboxamide::US10343992, Example 221::US10689345, Example 221::US11053198, Example 221::US11066365, Example 227::US11390584, Example 221::US20230303547, Reference Example A

SMILES COc1cccc(c1)-c1cc(on1)C(=O)N[C@@H]1CCN(C1)C#N

InChI Key InChIKey=ZIVSOTIVNKAORH-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 404569   

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Mission Therapeutics

US Patent
LigandPNGBDBM404569((R)-N-(1-cyanopyrrolidin-3-yl)-3-(3-methoxyphenyl)...)
Affinity DataIC50: 68nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 µM for a final concentration of 100 µM) in 50% DMSO in a 96-well polypropylen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Mission Therapeutics

US Patent
LigandPNGBDBM404569((R)-N-(1-cyanopyrrolidin-3-yl)-3-(3-methoxyphenyl)...)
Affinity DataIC50: 100nMAssay Description:USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2021
Entry Details
US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Mission Therapeutics

US Patent
LigandPNGBDBM404569((R)-N-(1-cyanopyrrolidin-3-yl)-3-(3-methoxyphenyl)...)
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Mission Therapeutics

US Patent
LigandPNGBDBM404569((R)-N-(1-cyanopyrrolidin-3-yl)-3-(3-methoxyphenyl)...)
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2020
Entry Details
US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Mission Therapeutics

US Patent
LigandPNGBDBM404569((R)-N-(1-cyanopyrrolidin-3-yl)-3-(3-methoxyphenyl)...)
Affinity DataIC50: 100nMAssay Description:USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Mission Therapeutics

US Patent
LigandPNGBDBM404569((R)-N-(1-cyanopyrrolidin-3-yl)-3-(3-methoxyphenyl)...)
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Mission Therapeutics

US Patent
LigandPNGBDBM404569((R)-N-(1-cyanopyrrolidin-3-yl)-3-(3-methoxyphenyl)...)
Affinity DataIC50: 550nMAssay Description:USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2021
Entry Details
US Patent