BDBM404478 (R)-N-(1-cyanopyrrolidin- 3-yl)-5-(1-methyl-1H- pyrazol-4-yl)-1H-indole- 2-carboxamide::US10343992, Example 130::US10689345, Example 130::US11066365, Example 130

SMILES Cn1cc(cn1)-c1ccc2[nH]c(cc2c1)C(=O)N[C@@H]1CCN(C1)C#N

InChI Key InChIKey=UMJNRKKTDHUXSS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 404478   

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Missions Therapeutics

US Patent
LigandPNGBDBM404478((R)-N-(1-cyanopyrrolidin- 3-yl)-5-(1-methyl-1H- py...)
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2020
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Missions Therapeutics

US Patent
LigandPNGBDBM404478((R)-N-(1-cyanopyrrolidin- 3-yl)-5-(1-methyl-1H- py...)
Affinity DataIC50: 100nMAssay Description:USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Missions Therapeutics

US Patent
LigandPNGBDBM404478((R)-N-(1-cyanopyrrolidin- 3-yl)-5-(1-methyl-1H- py...)
Affinity DataIC50: 100nMAssay Description:USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2021
Entry Details
Go to US Patent