BDBM404429 (R)-N-(1-cyanopyrrolidin-3-yl)-4- (1-ethyl-1H-pyrazol-4-yl)-2- fluorobenzamide::US10343992, Example 81::US10689345, Example 81::US11066365, Example 81::US11390584, Example 81

SMILES CCn1cc(cn1)-c1ccc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1

InChI Key InChIKey=PZUXVMXBCUMLGE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 404429   

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Missions Therapeutics

US Patent
LigandPNGBDBM404429((R)-N-(1-cyanopyrrolidin-3-yl)-4- (1-ethyl-1H-pyra...)
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2020
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Missions Therapeutics

US Patent
LigandPNGBDBM404429((R)-N-(1-cyanopyrrolidin-3-yl)-4- (1-ethyl-1H-pyra...)
Affinity DataIC50: 100nMAssay Description:USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Missions Therapeutics

US Patent
LigandPNGBDBM404429((R)-N-(1-cyanopyrrolidin-3-yl)-4- (1-ethyl-1H-pyra...)
Affinity DataIC50: 100nMAssay Description:USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2021
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Missions Therapeutics

US Patent
LigandPNGBDBM404429((R)-N-(1-cyanopyrrolidin-3-yl)-4- (1-ethyl-1H-pyra...)
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent